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However, overproduction of ROS pushes the cellular redox balance towards an oxidative state linked to several male fertility problems, including varicocele, leukocytospermia, and idiopathic infertility [18,89]

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Another extracellular mechanism for triggering cell death involves the interaction of receptors and ligands, such as the Fas/FasL system, which can also initiate apoptotic events under certain conditions (Yamada et al., 2017)